Adipose tissue signaling in aldosterone-producing adenomas: paracrine and endocrine effects
Authors' conclusion
RNA sequencing identified significant gene expression differences in fat compartments of APA patients, implying endocrine and paracrine effects of APAs. These findings might partly explain cardiovascular consequences of primary aldosteronism and could lead to new diagnostic strategies, especially through accessible scAT.
Study context
- Population
- Patients with aldosterone-producing adenomas and, as controls, nonfunctional adrenal adenomas; subcutaneous and periadrenal adipose tissue
- Comparison
- APA vs NFA adipose tissue
- Outcome
- Differentially expressed genes (RNA sequencing)
Methodological detailsRNA sequencing, immunohistochemistry, KCNJ5-mutated APA subanalysis
- RNA sequencing
- Immunohistochemistry
- KCNJ5-mutated APA subanalysis
Main finding
As reported in the abstract
APA vs NFA in subcutaneous adipose tissue (scAT) (up, down)
68 up, 259 down
APA vs NFA in periadrenal adipose tissue (paAT) (up, down)
16 up, 117 down
scAT vs paAT of APA patients (up, down)
826 up, 1632 down
Original publication
Adipose tissue signaling in aldosterone-producing adenomas: paracrine and endocrine effects. Eur J Endocrinol. Published 24 September 2025. doi:10.
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