Adiponectin and Glucocorticoids Modulate Risk for Preterm Birth: The Healthy Start Study
Authors' conclusion
Overall, metabolic and stress biomarkers are associated with preterm birth in this healthy cohort. We identify a possible mechanistic link between maternal stress and metabolism for pregnancy maintenance.
Study context
- Population
- Low-risk singleton pregnancies, Healthy Start Studymatched 1:3
- Participants
- 16 vs 46
- Comparison
- Preterm vs term birth
- Pretermn = 16
- Termn = 46reference
- Outcome
- LMW adiponectin and cortisone
- Follow-up
- 15w0d
Methodological detailsmatched 1:3, biobanked fasting maternal plasma
- Matched 1:3
- Biobanked fasting maternal plasma
Main finding
As reported in the abstract
15w0d
- Preterm had lower cortisol to cortisone and lower low molecular weight (LMW) adiponectin to cortisol ratios
- Preterm vs Term: P = 0.045
- Preterm vs Term: P = 0.031
Observational data: associations, not effects.
Further findings
Prediction of preterm birth (high molecular weight (HMW) adiponectin, cortisol/cortisone ratio, cortisone, maternal height, age, prepregnancy BMI)
- AUC
- 0.8167
Biomarkers and self-reported psychosocial stress
- Lower perceived stress associated with steeper change in cortisone in Term
Original publication
Adiponectin and Glucocorticoids Modulate Risk for Preterm Birth: The Healthy Start Study. J Clin Endocrinol Metab. Published 9 July 2024. doi:10.
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