Accuracy and Feasibility of a Novel Glucose/Lactate Continuous Multi-Analyte Sensing Platform in Humans
Authors' conclusion
Our initial data support safety and functionality of a novel glucose/lactate continuous multi-analyte sensor. Further sensor refinement will improve run-in performance and accuracy.
Study context
- Population
- Adults with diabetes; 7 female; mean age 43 years (SD 16); BMI 27 kg/m² (SD 5)11 analysed
- Participants
- 16 adults
- Comparison
- Investigational glucose/lactate multi-analyte sensor vs Guardian 3 CGM, benchmarked against venous YSI
- Outcome
- Safety and function of the glucose/lactate multi-analyte sensor vs venous YSI glucose and lactate
- Follow-up
- Day 1 and day 4 of wear
Methodological detailsfirst-in-human, pilot, Meal-test followed by exercise challenge on day 1 and day 4 of wear
- First-in-human
- Pilot
- Meal-test followed by exercise challenge on day 1 and day 4 of wear
Performance
As reported in the abstract
Glucose MARD vs YSI · overall
Glucose MARD vs YSI · overall
Median MARD
Further findings
Investigational glucose sensor mean absolute relative difference (MARD) by day
- MARD day 4
- 13.9%
- MARD day 1
- 15.2%
- Improved on day 4
Lactate sensor readings within 20/20% and 40/40% of YSI
- Within 20/20%
- 59.7%
- Within 40/40%
- 83.1%
Original publication
Accuracy and Feasibility of a Novel Glucose/Lactate Continuous Multi-Analyte Sensing Platform in Humans. J Diabetes Sci Technol. Published 29 July 2024. doi:10.
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