Accelerated waning of the humoral response to COVID-19 vaccines in obesity
Main finding · COVID-19 hospitalisation or death in vaccinated individualsResult — go to the resultAdjusted rate ratio 1.76 95% CI 1.60–1.94Authors' conclusion
We demonstrate that waning of COVID-19 vaccine-induced humoral immunity is accelerated in individuals with severe obesity.
Study context
- Population
- 3.6 million people in Scotland (EAVE II); prospective cohort of individuals with severe obesity vs normal body mass index (BMI) after COVID-19 vaccination3.6 million in EAVE II
- Participants
- 28 vs 41
- Exposure
- Severe obesity vs normal BMI
- Severe obesityn = 28
- Normal BMIn = 41reference
- Outcome
- COVID-19 hospitalisation or death in vaccinated individuals
Methodological detailsEAVE II surveillance platform
- EAVE II surveillance platform
Main finding
As reported in the abstract
Adjusted rate ratio
1.76
95% CI 1.60–1.94
Severe obesityvs Normal BMI
adjusted rate ratio 1.76 (95% CI 1.60–1.94)
Observational data: associations, not effects.
Further findings
Unquantifiable neutralizing antibody titers against authentic SARS-CoV-2 · 6 months after second vaccine dose
P = 0.0003
Neutralizing capacity relative to anti-spike and anti-RBD antibody level
- At any given anti-spike and anti-RBD antibody level, neutralizing capacity lower with severe obesity than normal BMI
Neutralizing capacity after third dose
- Restored by third dose but declined more rapidly with severe obesity
Original publication
Accelerated waning of the humoral response to COVID-19 vaccines in obesity. Nat Med. Published 11 May 2023. doi:10.
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