Abaloparatide and pelvic fracture healing: a phase 2 randomized placebo-controlled trial
Authors' conclusion
In this small study, there was no significant difference in CT radiologic healing, physical performance, or change in pain with ABL vs. placebo in patients with acute pelvic fracture.
Study context
- Population
- Postmenopausal women and men ≥ 50 years old, enrolled within 4 weeks of pelvic fracture; mean age 82, 93% female
- Participants
- 48 women
- Comparison
- Abaloparatide vs placebo
- Primary endpoint
- Fracture healing: CT cortical bridging score on a 5-point scale, assessed by two radiologists
- Follow-up
- 3 months
Methodological detailsphase 2, blinded, placebo-controlled
- Phase 2
- Blinded
- Placebo-controlled
Primary result
As reported in the abstract
CT bridging score distribution
- No significant difference in bridging score distribution with abaloparatide (ABL) vs placebo (PBO)
- ABL vs PBO: P = 0.15
Further findings
| Outcome | ABL | PBO | RR (95% CI) | |
|---|---|---|---|---|
| Healed patients (3 or 4 cortices bridged) · 3 months | 39% | 64% | 0.61 (0.33–1.12) | |
| Healed individual fractures (n = 81) · 3 months | 47% | 53% | 0.88 (0.55–1.40) | |
| 0.20.5125Relative risk (log scale) |
- Bridging scores, individual fractures (n = 81) · 3 months
- P = 0.13
- Numeric Rating Scale (NRS) pain score
- P < 0.05
- NRS pain score: baseline; least square means controlling for age, sacral, and displaced fracture
Bridging scores, individual fractures (n = 81) · 3 months
- Similar bridging scores with ABL and PBO
NRS pain score
- NRS pain higher with PBO than ABL at baseline; no further group differences in change in pain score
Short Physical Performance Battery (SPPB) and TUG
- SPPB and TUG scores improved over time in both groups without group differences
Original publication
Abaloparatide and pelvic fracture healing: a phase 2 randomized placebo-controlled trial. Osteoporos Int. Published 20 August 2026. doi:10.
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