A two‐decade population‐based study on the effect of hypertension in the general population with obesity in the United States
Authors' conclusion
The incremental mortality risk in controlled and uncontrolled hypertension, compared with the normotensive counterparts, irrespective of sex, age, and diabetes status, urges health care providers to optimize hypertension control and advocate weight loss to achieve better outcomes in obesity.
Study context
- Population
- US general population with obesity, National Health and Nutrition Examination Survey 1999–2018
- Participants
- 16,386 participants
- Exposure
- Controlled and uncontrolled hypertension vs no hypertension in obesity
- Outcome
- All-cause mortality
Methodological detailsNHANES 1999–2018, Cox regression adjusted for age, sex, ethnicity, diabetes and previous MI
- NHANES 1999–2018
- Cox regression adjusted for age, sex, ethnicity, diabetes and previous MI
Main finding
As reported in the abstract
Each group vs no hypertensionHazard ratio (95% CI)P value
Uncontrolled hypertension
1.34(1.13–1.59)
P = 0.001Controlled hypertension
1.21(1.10–1.34)
P < 0.001Observational data: associations, not effects.
Further findings
Distribution of hypertension status
Excess mortality by subgroup
- Excess mortality trend more pronounced in females, those with diabetes, and those older than 65 years
Original publication
A two‐decade population‐based study on the effect of hypertension in the general population with obesity in the United States. Obesity (Silver Spring). Published 7 February 2023. doi:10.
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