A study on the efficacy and safety of fosfomycin for the treatment of Multidrug-Resistant Enterobacterales urinary tract infection in North Indian type 2 diabetes mellitus patients
Authors' conclusion
Fosfomycin appears to be an effective and well-tolerated therapeutic option for type 2 diabetes mellitus patients with MDRE UTIs in our study
Study context
- Population
- T2D patients with multidrug-resistant Enterobacterales (MDRE) urinary tract infection (UTI) at a tertiary care centre in North India; mean age 54.32 years, 68.49 % female
- Participants
- 73 patients
- Outcome
- Clinical and microbiological efficacy of oral fosfomycin
Methodological detailssingle-centre, single-arm
- Single-centre
- Single-arm
Main finding
As reported in the abstract
- Clinical improvement, men
- 91 %
- Clinical improvement, women
- 98 %
- Microbiological improvement, males
- 82.6 %
- Microbiological improvement, females
- 90 %
- Recovered both clinically and microbiologically, overall
- 78.1 %
Observational data: associations, not effects.
Further findings
Prevalence of uropathogens
%
- E. coli
- 42.4
- Klebsiella
- 31.5
Safety
- Fosfomycin was well tolerated in general, with minimal side effects
Original publication
A study on the efficacy and safety of fosfomycin for the treatment of Multidrug-Resistant Enterobacterales urinary tract infection in North Indian type 2 diabetes mellitus patients. Diabetes Res Clin Pract. Published 20 June 2026. doi:10.
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