A Meta-Analysis of Randomized Trial Outcomes for the t:slim X2 Insulin Pump with Control-IQ Technology in Youth and Adults from Age 2 to 72
Pooled result · TIR 70-180 mg/dLResult — go to the resultAdjusted treatment group difference 11.5% 95% CI +9.7% to +13.2%Authors' conclusion
This pooled analysis of Control-IQ RCTs demonstrates the beneficial effect of Control-IQ in T1D across a broad spectrum of participant characteristics, including racial-ethnic minority, lower SES, lack of prestudy insulin pump experience, and high HbA1c levels. The greatest benefit was observed in participants with the worst baseline glycemic control in whom the auto-bolus feature of the Control-IQ algorithm appears to have substantial impact.
Study context
- Population
- Participants with T1D aged 2 to 72 years
- Participants
- 369 participants3 randomized controlled trials (RCTs)
- Comparison
- Control-IQ hybrid closed loop vs Control
- Control-IQn = 256
- Controln = 113reference
- Outcome
- TIR 70-180 mg/dL across subgroups by baseline characteristics (race/ethnicity, socioeconomic status (SES), prestudy insulin delivery modality, baseline glycemic control)
Methodological detailsindividual participant data pooled from 3 RCTs, subgroup analysis
- Individual participant data pooled from 3 RCTs
- Subgroup analysis
Pooled result
TIR 70-180 mg/dL · follow-up
Adjusted treatment group difference
11.5%
95% CI +9.7% to +13.2%
P < 0.001
By group
Control-IQvs Control
adjusted treatment group difference 11.5% (95% CI +9.7% to +13.2%); P < 0.001
As reported in the abstract
Further pooled results
| Outcome | Control-IQ | Control |
|---|---|---|
| TIR 70-180 mg/dL at baseline | 57% ± 17% | 56% ± 15% |
Mean glucose, hyperglycemia and hypoglycemic metrics, HbA1c
- Significant reductions in mean glucose, hyperglycemia metrics, hypoglycemic metrics and HbA1c
Original publication
A Meta-Analysis of Randomized Trial Outcomes for the t:slim X2 Insulin Pump with Control-IQ Technology in Youth and Adults from Age 2 to 72. Diabetes Technol Ther. Published 12 April 2023. doi:10.
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