CurrentEndo — Adrenal disease

Noninvasive serum steroid signatures of lateralization and coexisting cortisol excess in primary aldosteronism

2026-11-13T18:46:09.627Z

Diagnostic or prognostic study · J Clin Endocrinol Metab, 2026.

Individualized Glucocorticoid Replacement with Prednisone in Central Adrenal Insufficiency Using a Clinical Dose-Finding Algorithm

2026-11-13T17:46:43.542Z

Cohort study · Endocr Pract, 2026.

Home Waking Salivary Cortisone to Screen for Adrenal Insufficiency

2026-11-13T11:02:52.866Z

Diagnostic or prognostic study · NEJM Evid, 2023. Diagnostic accuracy of waking salivary cortisone for AI: Waking salivary cortisone: AUC 0.95 (95% CI, 0.92 to 0.97); NPV 96% (95% CI, 90 to 99); PPV 95% (95% CI, 87 to 99)

[11C]metomidate PET-CT versus adrenal vein sampling for diagnosing surgically curable primary aldosteronism: a prospective, within-patient trial

2026-11-13T11:02:00.546Z

Diagnostic or prognostic study · Nat Med, 2023. 6- to 9-month follow-up: MTO 72.7 %; accuracy, biochemical success 72.7; accuracy, clinical success 65.4% · AVS 63.6 %; accuracy, biochemical success 63.6; accuracy, clinical success 61.5%

Accuracy of Gallium-68 Pentixafor Positron Emission Tomography–Computed Tomography for Subtyping Diagnosis of Primary Aldosteronism

2026-11-13T11:00:06.281Z

Diagnostic or prognostic study · JAMA Netw Open, 2023. Identification of UPA by lateralization index based on SUVmax at 10 minutes: Gallium-68 pentixafor PET-CT: AUROC 0.90 (95% CI, 0.83-0.97); specificity (cutoff 1.65) 1.00 (95% CI, 0.94-1.00); sensitivity (cutoff 1.65) 0.77 (95% CI, 0.61-0.88)

Ethnic and National Differences in Congenital Adrenal Hyperplasia Incidence: A Systematic Review and Meta-Analysis

2026-11-13T10:10:38.237Z

Meta-analysis · Horm Res Paediatr, 2022. Overall CAH incidence: Overall CAH incidence 1:9,498 (95% CI 1:9,089, 1:9,945)

Glucocorticoid Receptor Expression Pattern in Very Low Birth Weight Infants Changes Drastically within the First Week of Life

2026-11-13T10:10:38.237Z

Cohort study · Horm Res Paediatr, 2022. GRα/GRβ expression ratio change in VLBW infants (fold change), day 0 to days 4-7: VLBW day 0 median 1.0 (IQR 0.6-1.4) fold change · VLBW days 4-7 median 1.7 (IQR 0.6-1.4) fold change

Infants with Congenital Adrenal Hyperplasia Exhibit Thalamic Discrepancies in Early Brain Structure

2026-11-13T10:10:38.237Z

Cross-sectional study · Horm Res Paediatr, 2023. Thalamic volume (adjusted for PCA and sex): CAH mean 8,606 (95% CI 8,209, 9,002) mm3 · Controls mean 9,215 (95% CI 8,783, 9,647) mm3

Salivary 17-Hydroxyprogesterone Levels in Children with Congenital Adrenal Hyperplasia: A Retrospective Longitudinal Study Considering Auxological Parameters

2026-11-13T10:10:38.237Z

Cohort study · Horm Res Paediatr, 2022. Salivary 17-OHP (s17-OHP), total cohort, median observation 5.5 years per patient: Median s17-OHP, morning 67.8 pg/mL

Cushing’s syndrome in women: age-related differences in etiology and clinical picture

2026-11-13T10:09:36.510Z

Cohort study · Pituitary, 2022. Pituitary etiology: ≤ 45 70.6% · ≥ 65 31.6%

Evaluation of Body Composition in Patients With and Without Adrenal Tumors and Without Overt Hypersecretory Syndromes

2026-11-13T10:04:31.875Z

Cross-sectional study · Endocr Pract, 2022. Serum cortisol post-DST vs subcutaneous fat area (computed tomography (CT)), weak positive correlation r = 0.3, P =.048

Factors Predicting Long-term Estimated Glomerular Filtration Rate Decrease, a Reliable Indicator of Renal Function After Adrenalectomy in Primary Aldosteronism

2026-11-13T10:04:31.875Z

Meta-analysis · Endocr Pract, 2022. Preoperative factors associated with long-term eGFR decrease after adrenalectomy: Old age: OR 1.05, 95% CI 1.02-1.09, P = .001

Transition Readiness in Adolescents and Young Adults Living With Congenital Adrenal Hyperplasia

2026-11-13T10:04:31.875Z

Cohort study · Endocr Pract, 2023. Good transition readiness: Good transition readiness 26 (68%)

Adrenal incidentaloma: Do patients with apparently nonfunctioning mass or autonomous cortisol secretion have similar or different clinical and metabolic features?

2026-11-13T09:59:57.591Z

Cross-sectional study · Clin Endocrinol (Oxf), 2023. Cardiometabolic morbidities, adrenal incidentaloma vs controls — Adrenal incidentaloma vs Controls: hypertension 74.1 vs. 57.8%; p = .02; higher frequency with adrenal incidentaloma

Adrenal venous sampling for lateralization of cortisol hypersecretion in patients with bilateral adrenal masses

2026-11-13T09:59:57.591Z

Cohort study · Clin Endocrinol (Oxf), 2022. Unilateral mean 12.1 ± 9.6; AV/inferior vena cava (IVC) cortisol ratio, contralateral (mean ± ) 4.7 ± 3.8; Cortisol lateralization ratio (CLR) (mean ±) 3.6 ± 3.5 · Bilateral mean 7.5 ± 2.1; CLR (mean ±) 1.1 ± 0.6

Characterisation of the urinary steroid profile of patients with nonfunctioning adrenal incidentalomas: A matched controlled cross‐sectional study

2026-11-13T09:59:57.591Z

Cross-sectional study · Clin Endocrinol (Oxf), 2022. Urinary steroid excretion, NFAI vs healthy-adrenal — NFAI vs Healthy-adrenal; p = .046; Androgen metabolites lower with NFAI: 230.5 ± 190.12 vs. 388.7 ± 328.58 µg/24 h

Clinical, imaging and biochemical presentation of cystic pheochromocytomas

2026-11-13T09:59:57.591Z

Cohort study · Clin Endocrinol (Oxf), 2022. Clinical, imaging and biochemical characteristics: Prevalence of cystic pheochromocytoma among pheochromocytomas 21 (3.2%)

COVID‐19‐related adrenal haemorrhage: Multicentre UK experience and systematic review of the literature

2026-11-13T09:59:57.591Z

Meta-analysis · Clin Endocrinol (Oxf), 2023. Characteristics of COVID-19-related AH: Infection-related AH: bilateral 4

Electrolyte abnormalities and stress dosing predict illness‐related hospitalizations among infants and toddlers with congenital adrenal hyperplasia

2026-11-13T09:59:57.591Z

Cohort study · Clin Endocrinol (Oxf), 2023. Rate of emergency department (ED) visits: CAH 0.50 (range 0.25-0.88) per person-year · Controls 0 (range 0-0) per person-year

Fertility and pregnancy outcomes in women with nonclassic 21‐hydroxylase deficiency

2026-11-13T09:59:57.591Z

Cohort study · Clin Endocrinol (Oxf), 2022. Fertility and pregnancy outcomes: Women with pregnancies 86

Long‐term effects of primary aldosteronism treatment on patients with primary aldosteronism and chronic kidney disease

2026-11-13T09:59:57.591Z

Cohort study · Clin Endocrinol (Oxf), 2022. Reduction in eGFR 1 month after treatment, CKD group: ADX mean -20.1 ± 8.2 ml/min/1.73 m2 · MRA mean -9.2 ± 5.9 ml/min/1.73 m2

Measuring steroids in hair opens up possibilities to identify congenital adrenal hyperplasia in developing countries

2026-11-13T09:59:57.591Z

Diagnostic or prognostic study · Clin Endocrinol (Oxf), 2022. Hair steroid concentrations in untreated CAH patients vs upper limit of healthy volunteer range, before treatment: CAH: 17OHP range 9.43-1135 pmol/g; androstenedione range 36.1-432 pmol/g; testosterone range 2.85-69.2 pmol/g · Healthy volunteers: 17OHP upper limit 5.5 pmol/g; androstenedione upper limit 13 pmol/g; testosterone upper limit 1.8 pmol/g

Prognostic value of contralateral suppression on kidney function after surgery in patients with primary aldosteronism

2026-11-13T09:59:57.591Z

Cohort study · Clin Endocrinol (Oxf), 2022. Change in eGFR after adrenalectomy: CLS mean 17.5 ± 17.6; direction reduction · No CLS mean 1.8 ± 12.8; direction increase

Radiation of bilateral adrenal metastases is associated with a high risk of primary adrenal insufficiency

2026-11-13T09:59:57.591Z

Cohort study · Clin Endocrinol (Oxf), 2023. PAI after adrenal RT, median 6.1 months (IQR 3.9-13.8) after RT: Developed PAI 8 (14.3%)

Side‐chain cleavage enzyme deficiency: Systematic review and case series

2026-11-13T09:59:57.591Z

Meta-analysis · Clin Endocrinol (Oxf), 2022. SCCD-TMG vs SCCD-AG: spontaneous puberty 9/9 vs. 0/3; p = .0045; more common in SCCD-TMG

The utility of a random cortisol level in determining neonatal central adrenal insufficiency

2026-11-13T09:59:57.591Z

Cohort study · Clin Endocrinol (Oxf), 2023. Random serum cortisol: CAI mean 1.98 ± 1.88 mcg/dl · ARF-CAI mean 6.27 ± 5.48 mcg/dl · non-CAI mean 4.6 ± 4.02 mcg/dl

International multicenter survey on screening and confirmatory testing in primary aldosteronism

2026-11-13T09:58:18.729Z

Cross-sectional study · Eur J Endocrinol, 2023. Diagnostic approaches for PA across centers: Prominent diversity in blood-sampling conditions, aldosterone and renin assay methods, and methods and diagnostic cutoffs for screening and confirmatory tests

Lack of sensitivity of diagnostic Cushing-scores in Germany: a multicenter validation

2026-11-13T09:58:18.729Z

Diagnostic or prognostic study · Eur J Endocrinol, 2023. Proven CS not recommended for biochemical screening; patients without CS recommended for screening: Spanish score: Proven CS not recommended for screening 17.5%; Pituitary CS not recommended 22%; Adrenal CS not recommended 10%; Without CS recommended for screening 14% · Italian score: Proven CS in low-risk classes not recommended for screening 29%; Adrenal CS not recommended 31%; Pituitary CS not recommended 30%; Without CS recommended for screening About 12%

Modified-release hydrocortisone is associated with lower plasma renin activity in patients with salt-wasting congenital adrenal hyperplasia

2026-11-13T09:58:18.729Z

Secondary analysis · Eur J Endocrinol, 2023. Plasma renin activity (PRA), change from baseline, baseline to 24 weeks: MR-HC median 0.83 to 0.48 (IQR 1.0 to 0.61) ng L-1 s-1; P (within-group change) P = .012 · Standard GC median 0.53 to 0.52 (IQR 0.66 to 0.78) ng L-1 s-1; P (within-group change) P = .613

Replication of association at the LPP and UBASH3A loci in a UK autoimmune Addison's disease cohort

2026-11-13T09:58:18.729Z

Case-control study · Eur J Endocrinol, 2023. Association of alleles with AAD: LPP allele association with AAD, OR 1.46 (1.21-1.75) (95% CI)

Saline suppression to distinguish the primary aldosteronism subtype: a diagnostic study

2026-11-13T09:58:18.729Z

Diagnostic or prognostic study · Eur J Endocrinol, 2023. Specificity for predicting bilateral PA: Australian: specificity 88.2% · Chinese: specificity 97.0% · Japanese: specificity 100.0%

Self-management and hospitalization in 615 Swedish patients with Addison's disease during the coronavirus disease 2019 pandemic: a retrospective study

2026-11-13T09:58:18.729Z

Cohort study · Eur J Endocrinol, 2023. COVID-19 reported: COVID-19 reported 17%

The ultra-acute steroid response to traumatic injury: a cohort study

2026-11-13T09:58:18.729Z

Cohort study · Eur J Endocrinol, 2023. Serum steroids, within 1 h of injury: Increase in glucocorticoid and adrenal androgen biosynthesis

Efficacy and Safety of Tyrosine Kinase Inhibitors in Patients with Metastatic Pheochromocytomas/Paragangliomas

2026-11-13T09:55:31.327Z

Meta-analysis · J Clin Endocrinol Metab, 2022. Tumour response (pooled proportions; 5 studies): Pooled proportion of PR 0.320 (95% CI 0.155-0.486)

Exclusion Tests in Unilateral Primary Aldosteronism (ExcluPA) Study

2026-11-13T09:55:31.327Z

Meta-analysis · J Clin Endocrinol Metab, 2022. Pooled accuracy (summary area under the ROC curve (sAUROC)): ARR 0.95 (95% CI 0.92-0.98); sAUROC 0.95 · CCT 0.92 (95% CI 0.88-0.97); sAUROC 0.92 · SIT 0.96 (95% CI 0.94-0.99); sAUROC 0.96

Impaired Cognitive Function in Patients With Autonomous Cortisol Secretion in Adrenal Incidentalomas

2026-11-13T09:55:31.327Z

Cohort study · J Clin Endocrinol Metab, 2022. Neurocognitive function — ACS vs NFA; P < 0.05; subjective memory complaints 40.7% vs 13.9%, higher with ACS

Implication of MR Activity in Posttreatment Arterial Stiffness Reversal in Patients With Primary Aldosteronism

2026-11-13T09:55:31.327Z

Cohort study · J Clin Endocrinol Metab, 2022. Improvement in PWV after treatment, 12 months — Group 2 vs Group 1: ΔPWV; P = .007; lower ΔPWV with group 2

Leukocyte Telomere Length in Children With Congenital Adrenal Hyperplasia

2026-11-13T09:55:31.327Z

Cohort study · J Clin Endocrinol Metab, 2022. LTL — Classic CAH vs Nonclassic CAH: -0.29; P = 0.012; shorter with classic CAH

Recurrent Disease in Patients With Sporadic Pheochromocytoma and Paraganglioma

2026-11-13T09:55:31.327Z

Cohort study · J Clin Endocrinol Metab, 2022. Prevalence of recurrence: Sporadic PPGL 14.7% · Pseudohypoxia variants 47.5% · Kinase variants 14.9%

Clinical consensus guideline on the management of phaeochromocytoma and paraganglioma in patients harbouring germline SDHD pathogenic variants

2026-11-13T09:54:14.154Z

Guideline or statement · Lancet Diabetes Endocrinol, 2023.

International Newborn Screening Practices for the Early Detection of Congenital Adrenal Hyperplasia

2026-11-13T04:57:29.624Z

Cross-sectional study · Horm Res Paediatr, 2023. CAH newborn screening (NBS) protocols: Recommend sampling at 48-72 h of life 14 (61%)

Evaluating the burden of endogenous Cushing’s syndrome using a web-based questionnaire and validated patient-reported outcome measures

2026-11-13T04:56:40.988Z

Cross-sectional study · Pituitary, 2023. Burden of illness: Mean gap between first symptoms and diagnosis 10 years

“A morning cortisol is the most effective clinical predictor of short synacthen test outcome”: A tertiary care centre experience

2026-11-13T04:51:33.591Z

Cohort study · Clin Endocrinol (Oxf), 2023. Predictors of SST pass; pretest morning cortisol threshold predicting SST pass with 100% specificity: Group 1 ≥300 nmol/L; ROC AUC 0.763; 95% CI 0.675 to 0.850; P p < 0.001; specificity 100% · Group 2 ≥340 nmol/L; ROC AUC 0.688; 95% CI 0.615 to 0.761; P p < 0.001; specificity 100% · Group 3 ≥376 nmol/L; ROC AUC 0.783; 95% CI 0.708 to 0.859; P p < 0.001; specificity 100%

Adrenal and juxta‐adrenal schwannomas: A single‐centre study

2026-11-13T04:51:33.591Z

Cohort study · Clin Endocrinol (Oxf), 2023. Clinical, biochemical and imaging characteristics, at diagnosis: Discovered incidentally on imaging 21, 88%

Do multiple types of confirmatory tests improve performance in predicting subtypes of primary aldosteronism?

2026-11-13T04:51:33.591Z

Cross-sectional study · Clin Endocrinol (Oxf), 2022. AUC for PA subtype prediction (test data set): SIT + CCT: AUC 0.850 · SIT: AUC 0.813 · CCT: AUC 0.786

Evaluation of aggression level in adolescent girls with classical congenital adrenal hyperplasia

2026-11-13T04:51:33.591Z

Cross-sectional study · Clin Endocrinol (Oxf), 2023. Total aggression scale score (BPAS): Girls with CAH 73.3 ± 14.6 · Healthy girls 74.1 ± 11.2 · Boys with CAH 71.5 ± 14.8 · Healthy boys 75.3 ± 14.5

Genotype‐phenotype association in congenital adrenal hyperplasia due to 21‐hydroxylase deficiency in children

2026-11-13T04:51:33.591Z

Cross-sectional study · Clin Endocrinol (Oxf), 2022. Genotype–phenotype correspondence: High correlation in groups with mutations of high and moderate severity (0 and A)

Late‐night salivary cortisol cut‐offs for diagnosis of Cushing syndrome using second‐generation electrochemiluminescence immunoassay kits

2026-11-13T04:51:33.591Z

Diagnostic or prognostic study · Clin Endocrinol (Oxf), 2023. Diagnostic performance of LNSC for CS: Cases vs all controls: AUC 0.994; cut-off ≥6.73 nmol/L; sensitivity 97.8%; specificity 94.8% · Cases vs overweight/obese controls: AUC 0.993; cut-off ≥7.26 nmol/L; sensitivity 97.8%; specificity 95.1%

Node‐by‐node diagnosis for multiple ipsilateral nodules by segmental adrenal venous sampling in primary aldosteronism

2026-11-13T04:51:33.591Z

Cohort study · Clin Endocrinol (Oxf), 2022. Node-by-node diagnosis by sAVS in patients with multiple ipsilateral nodules: Patients with two to three nodules on surgical side 11 (6.8%)

Overlooked complication of Cushing's syndrome: Reactivation of hepatitis B

2026-11-13T04:51:33.591Z

Cohort study · Clin Endocrinol (Oxf), 2022. HBV infection prevalence: Anti-HBc IgG positive 19 (26.3%)