Weight loss independent outcomes in type 2 diabetes mellitus and other metabolic comorbidities after Roux-en-Y gastric bypass and sleeve gastrectomy
Main finding · Complete T2D remissionResult — go to the resultOR for complete T2D remission 0.75 95% CI 0.60–0.93Authors' conclusion
RYGB is associated with a greater rate of T2D remission compared to SG. This study suggests that these improved outcomes are independent of the degree of weight loss.
Study context
- Population
- Patients with presurgical T2D undergoing RYGB or sleeve gastrectomy (SG), Swedish registriesmatched cohort
- Participants
- 1,440 patients
- Exposure
- RYGB vs SG
- RYGBn = 720reference
- SGn = 720
- Outcome
- Complete T2D remission
- Follow-up
- 2 years
Methodological details1:1 propensity score matching, matched on %TWL at nadir, Scandinavian Obesity Surgery Registry and Swedish National Diabetes Register
- 1:1 propensity score matching
- Matched on %TWL at nadir
- Scandinavian Obesity Surgery Registry and Swedish National Diabetes Register
Main finding
As reported in the abstract
OR for complete T2D remission
0.75
95% CI 0.60–0.93
P = 0.010
Events by group
SGvs RYGB
OR for complete T2D remission 0.75 (95% CI 0.60–0.93); P = 0.010
- Similar TWL (standardized mean difference)
- 0.12
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value | |
|---|---|---|---|
| Pharmacological T2D remissionLower remission with SG | OR for pharmacological T2D remission 0.71 (95% CI 0.56–0.88) | P = 0.002 | |
| Hypertension remissionLower remission with SG | OR for hypertension remission 0.70 (95% CI 0.52–0.94) | P = 0.019 | |
| Pharmacological dyslipidemia remission | OR for pharmacological dyslipidemia remission 0.83 (95% CI 0.66–01.04) | P = 0.11 | |
| MACE | HR for MACE 1.45 (95% CI 0.89–2.38) | P = 0.136 | |
| 0.512Ratio (log scale) |
Original publication
Weight loss independent outcomes in type 2 diabetes mellitus and other metabolic comorbidities after Roux-en-Y gastric bypass and sleeve gastrectomy. Int J Obes (Lond). Published 18 March 2026. doi:10.
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