Weight change and risk of obesity‐related complications: A retrospective population‐based cohort study of a UK primary care database
Authors' conclusion
Weight loss benefit is dependent on weight loss magnitude and initial BMI, and weight gain is associated with a similar risk increase. Four patterns of association were identified between degree of weight change, baseline BMI and 13 ORCs.
Study context
- Population
- Adults with obesity (>30 kg/m²) with weight change (−50% to +50%) between Years 1 and 4, UK Clinical Practice Research Datalink GOLD database
- Participants
- 418,774 adults
- Exposure
- Weight loss/gain between Years 1 and 4, stratified by baseline body mass index (BMI)
- Outcome
- Risk of developing 13 obesity-related complications (ORCs)
- Follow-up
- Median : 7 years
Methodological detailsUK Clinical Practice Research Datalink GOLD database, Cox proportional hazard models
- UK Clinical Practice Research Datalink GOLD database
- Cox proportional hazard models
Main finding
As reported in the abstract
- Impact of weight change on obesity-related complications (ORCs) generally dependent on baseline BMI; four clear patterns across the 13 outcomes
- Pattern 1: greatest weight loss benefit at low baseline BMI (T2D, sleep apnoea, hypertension, dyslipidaemia)
- Pattern 2: most weight loss benefit at lower baseline BMI, no significant weight loss effect at higher baseline BMI (asthma, hip/knee osteoarthritis, PCOS)
- Pattern 3: benefit with weight loss but no additional benefit with >10% weight loss (CKD, HF, AF, VTE)
- Pattern 4: no clear relationship between weight change and unstable angina/MI and depression
- Similar but opposite patterns for weight gain
Observational data: associations, not effects.
Original publication
Weight change and risk of obesity‐related complications: A retrospective population‐based cohort study of a UK primary care database. Diabetes Obes Metab. Published 7 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →