Vulvovaginal candidiasis and type 2 diabetes: A nationwide retrospective cohort study
Authors' conclusion
We found temporal associations between VVC and diabetes. The findings demonstrate that the presence of VVC may indicate a future diagnosis of diabetes, especially in women aged 55 years and older. This knowledge could be valuable for clinicians when treating women with VVC.
Study context
- Population
- Women aged 35–65 years in Sweden (2007–2018), primary healthcare
- Participants
- 1,838,929 women
- Exposure
- Preceding VVC vs no preceding VVC
- Outcome
- T2D (association between VVC and subsequent T2D)
Methodological detailsnationwide, primary healthcare, propensity-score-weighted analysis
- Nationwide
- Primary healthcare
- Propensity-score-weighted analysis
Main finding
As reported in the abstract
Diabetes
VVC
4.05 per 1000 person-years
95% CI 3.86–4.24
No VVC
3.06 per 1000 person-years
95% CI 3.05–3.08
VVC vs No VVCHazard ratio (95% CI)
Multivariable-adjusted model
1.41(1.28–1.55)
Propensity-score-weighted analysis
1.63(1.53–1.74)
Observational data: associations, not effects.
Further findings
- Diabetes incidence rate, women aged ≥55 years with VVC
- 9.56 · 95% CI 8.01–11.11
- Time between VVC and subsequent diabetes
- 0.57 · mean · range 0–2 · years
- Diabetes incidence rate, women aged ≥55 years with VVC: aged 55 years and older
Risk of diabetes by age
- Women with prior VVC seemed to have a stronger risk of diabetes with older age, particularly after age 55 years
Original publication
Vulvovaginal candidiasis and type 2 diabetes: A nationwide retrospective cohort study. Diabetes Obes Metab. Published 8 July 2024. doi:10.
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