Unravelling the heterogeneity of diabetes in chronic pancreatitis: Alpha and beta cell dysfunction and association with glycaemic control
Main finding · Glucagon response to arginine stimulationResult — go to the resultMean difference −19.3 pmol/L 95% CI −35.6 to −3.0Authors' conclusion
Diabetes in chronic pancreatitis is a heterogeneous entity. The presence of type 2 diabetes prior to chronic pancreatitis is associated with a reduced risk of alpha cell dysfunction and hypoglycaemia.
Study context
- Population
- Patients with chronic pancreatitis and insulin-treated diabetes
- Participants
- 26 patients
- Exposure
- Post-pancreatitis diabetes vs pre-pancreatitis diabetes
- Post-pancreatitis diabetesn = 13
- Pre-pancreatitis diabetesn = 13reference
- Outcome
- Glucagon response to arginine stimulation
Main finding
As reported in the abstract
Mean difference
−19.3 pmol/L
95% CI −35.6 to −3.0
Post-pancreatitis diabetesvs Pre-pancreatitis diabetes
mean difference −19.3 pmol/L (95% CI −35.6 to −3.0)
Observational data: associations, not effects.
Further findings
Time in level 2 hyperglycaemia (CGM) · 20 days
P = 0.02
- Time in level 1 and level 2 hypoglycaemia (CGM) · 20 days · level 1 hypoglycaemia; more with post-pancreatitis diabetes
- P = 0.03
- Time in level 1 and level 2 hypoglycaemia (CGM) · 20 days · level 2 hypoglycaemia; more with post-pancreatitis diabetes
- P = 0.05
C-peptide levels
- C-peptide levels similar between the groups
Correlation of low glucagon response with time in hypoglycaemia
- Rho
- −0.54, p < 0.01
Original publication
Unravelling the heterogeneity of diabetes in chronic pancreatitis: Alpha and beta cell dysfunction and association with glycaemic control. Diabet Med. Published 31 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →