Unraveling the genetic link: causal effects and PRS predictions of adiposity‐related health conditions in East Asian individuals

Lin, YJ; Li, JP; Liu, TY; Chiou, JS; Lu, HF; Ariyoshi, K; Uchiyama, S; Terao, C; Yang, JS; Chou, CH; Liang, WM; Chou, IC; Lin, CW; Lin, TH; Liao, CC; Huang, SM; Tsai, FJ

doi:10.1002/oby.24335

Unraveling the genetic link: causal effects and polygenic risk score (PRS) predictions of adiposity‐related health conditions in East Asian individuals

Obesity (Silver Spring)Published 14 Aug 2025Genome-wide association study with Mendelian randomization and polygenic risk score analysis

Read the original article ↗PubMed

Cite

Authors' conclusion

These findings reveal novel adiposity loci and underscore the clinical utility of adiposity-related genetics for personalized health.

Study context

Population: Taiwanese individuals from Taiwan Biobank; validation in China Medical University Hospital and Biobank Japan databases

Outcome: Genetic loci, causal effects and PRS predictions of adiposity

Methodological detailscross-trait genetic correlation, bidirectional Mendelian randomization, four East Asian biobanks

Cross-trait genetic correlation
Bidirectional Mendelian randomization
Four East Asian biobanks

Performance

As reported in the abstract

BMI loci identified, including novel loci

41

Body fat percentage (BFP) loci identified, including novel loci

22

Reference

Authors: Lin YJ, Li JP, Liu TY, Chiou JS, Lu HF, Ariyoshi K, et al.
All 17 authors
Lin YJ, Li JP, Liu TY, Chiou JS, Lu HF, Ariyoshi K, Uchiyama S, Terao C, Yang JS, Chou CH, Liang WM, Chou IC, Lin CW, Lin TH, Liao CC, Huang SM, Tsai FJ
Journal: Obesity (Silver Spring)
Published: 14 Aug 2025
DOI: 10.1002/oby.24335
PubMed: 40808477

Topic: Obesity

Key notes

Genetically predicted higher adiposity correlated with increased risk of metabolic syndrome, CVD, hypertension and elevated liver enzymes
Bidirectional MR: causal effect of adiposity on HbA1c, systolic blood pressure, liver enzymes and cholelithiasis, with no reverse causality

More notes

After adjusting for T2D, the effect on glycemic traits diminished
BMI and BFP PRS robustly predicted higher risk and earlier onset of T2D, hypertension, cholelithiasis and liver dysfunction
GWAS of BMI (n = 95,488) and body fat percentage (BFP; n = 83,448)

Original publication

Unraveling the genetic link: causal effects and PRS predictions of adiposity‐related health conditions in East Asian individuals. Obesity (Silver Spring). Published 14 August 2025. doi:10.1002/oby.24335

Read the original article ↗

Composed by AI from the published abstract and checked against it. How Briefs are made →