Total and Regional Fat-To-Muscle Mass Ratio in Relation to All-Cause and Cause-Specific Mortality in Men and Women
Authors' conclusion
Our study revealed statistically significant associations of total and regional FMR with mortality, providing new evidence that FMR may be a potentially useful indicator for assessing mortality risk.
Study context
- Population
- UK Biobank participants, men and women; fat and muscle mass by bioelectrical impedance
- Participants
- 337,951 participants
- Exposure
- Quintiles of total and regional fat-to-muscle mass ratio
- Outcome
- All-cause and cause-specific mortality
- Follow-up
- Median 12.58 years
Methodological detailsUK Biobank, Cox proportional-hazard regression, sex-stratified
- UK Biobank
- Cox proportional-hazard regression
- Sex-stratified
Main finding
As reported in the abstract
All-cause mortality
Quintile 5 vs Quintile 1Hazard ratio (95% CI)
Arm FMR, men
1.14(1.05–1.23)
Leg FMR, men
0.76(0.71–0.82)
Leg FMR, women
0.78(0.70–0.88)
- Shape of association: U-shaped for whole body and trunk, L-shaped for legs, J-shaped for arms
- P for nonlinearity <.001
- Risk reduction in quintiles 2 to 4 vs lowest quintile of whole body and trunk FMR, men
- 12% to 14%
- Risk reduction in quintiles 2 to 4 vs lowest quintile of whole body and trunk FMR, women
- 7% to 15%
- Deaths
- 22 391 (6.62%)
- Deaths from CVD
- 4427
- Deaths from cancer
- 11 740
- Deaths from respiratory disease
- 1458
Observational data: associations, not effects.
Further findings
- Associations between FMR and cause-specific mortality mostly similar to those for all-cause mortality
Original publication
Total and Regional Fat-To-Muscle Mass Ratio in Relation to All-Cause and Cause-Specific Mortality in Men and Women. J Clin Endocrinol Metab. Published 28 August 2024. doi:10.
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