Tissue origins of the plasma proteomic response to glucose ingestion in humans
Authors' conclusion
Our exploratory study identifies the proteomic response to glucose ingestion and demonstrates its reproducibility despite major shifts in glucose homeostasis.
Study context
- Population
- Healthy volunteers undergoing oral glucose tolerance tests (OGTTs) before and after 7 days of complete caloric restriction
- Participants
- 11 volunteers
- Comparison
- OGTT before vs after 7 days of complete caloric restriction
- Outcome
- Time-resolved plasma proteomic response to glucose ingestion (>2900 targets)
Methodological detailsexploratory, before-and-after (7 days of complete caloric restriction)
- Exploratory
- Before-and-after (7 days of complete caloric restriction)
Main finding
As reported in the abstract
Plasma proteomic response to glucose ingestion
- Proteins changed significantly after glucose ingestion, reproducible after 7 days without food
- 44 proteins
- Enrichment of the signature for 'stomach-specific' proteins
- 20-fold
- Proteins with robust evidence for a differential trajectory during both OGTTs (incl. WARS)
- four proteins
Further findings
Annexin A10 (ANXA10) origin
- Observational evidence suggests ANXA10 is secreted upon sensing increased gastric pH, with the stomach as major contributing tissue
Metabolic effect of 7 days of complete caloric restriction
- Profound metabolic shift with delayed insulin secretion and postprandial hyperglycaemia
WARS genetics
- Genetic association of plasma WARS with glucose homeostasis and coronary artery disease
Original publication
Tissue origins of the plasma proteomic response to glucose ingestion in humans. Diabetologia. Published 17 July 2026. doi:10.
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