The Role of Obstructive Sleep Apnea and Continuous Positive Airway Pressure (CPAP) Therapy in the Functional Hypogonadism of Male Patients With Severe Obesity
Authors' conclusion
Decompensated OSAS was found to correlate with low testosterone in men with severe obesity. Moreover, CPAP therapy was shown to improve TT independently of BMI changes.
Study context
- Population
- Male inpatients with complicated severe obesity, without known hypogonadism
- Participants
- 204 inpatients
- Outcome
- Low TT (≤10.4 nmol/L)
Methodological detailsconsecutive enrolment, longitudinal substudy
- Consecutive enrolment
- Longitudinal substudy
Main finding
As reported in the abstract
- Patients with low total testosterone (TT) (≤10.4 nmol/L)
- 127 of 204
- Factors independently associated with TT (multiple linear regression): Body mass index (BMI)
- P = .039
- T2D independently associated with TT
- P = .006
- C-reactive protein independently associated with TT
- P = .003
- Decompensated obstructive sleep apnea syndrome (OSAS) (Apnea/Hypopnea Index (AHI) or Oxygen Desaturation Index (ODI) >30 events/hour) independently associated with TT
- P = .014
Observational data: associations, not effects.
Further findings
TT after CPAP therapy (longitudinal study, 14 newly diagnosed patients) · 3 months
- TT higher after CPAP
- P = 0.009
- ODI associated with TT improvement, independently of BMI
- P = 0.04
Original publication
The Role of Obstructive Sleep Apnea and CPAP Therapy in the Functional Hypogonadism of Male Patients With Severe Obesity. J Clin Endocrinol Metab. Published 24 November 2025. doi:10.
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