The relationship between mental fatigue, depression, and cognition in Graves’ disease
Authors' conclusion
Mental fatigue and emotional distress are common in the hyperthyroid phase. These improve with treatment but are still more common in GD patients after 15 months of therapy than in controls. The residual mental fatigue is shown to be a phenomenon distinct from depression in this study. This indicates the importance of assessing mental fatigue in GD patients and underlines the need for rehabilitation and healthcare support as fatigue will have consequences for work ability.
Study context
- Population
- Premenopausal women with Graves' disease (GD), assessed during hyperthyroidism and after treatment, 15 months apart
- Participants
- 65 vs 65
- Comparison
- Premenopausal women with GD vs matched controls
- GDn = 65
- Controlsn = 65reference
- Outcome
- Mental fatigue, depression and anxiety in hyperthyroid phase
- Follow-up
- Hyperthyroid phase
Methodological detailsmatched controls
- Matched controls
Main finding
As reported in the abstract
Mental fatigue
all P < 0.001
Observational data: associations, not effects.
Further findings
Change in mental fatigue, depression and anxiety after treatment · 15 months
- Significant improvements in GD after treatment (all P < 0.001); unchanged in controls
Residual symptoms in GD after treatment · 15 months
- Residual mental fatigue
- 38%
- Mental fatigue without depression
- 23%
- Mental fatigue combined with depression
- 15%
- Self-reported cognitive complaints pronounced; cognitive tests revealed no deficiencies
Original publication
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