The outcome of abnormal glucose metabolism and its clinical features in patients with Cushing’s disease after curative surgery
Authors' conclusion
CD patients demonstrated a high incidence of abnormal glucose metabolism. Notably, approximately two-thirds demonstrated improved glucose metabolism one year after curative surgery, with the greatest improvements observed at 3- to 6-month postoperative follow-up.
Study context
- Population
- Patients with Cushing's disease (CD) in biochemical remission after surgery, with regular postoperative follow-up
- Participants
- 151 patients
- Outcome
- Glucose metabolism after curative surgery
- Follow-up
- 1 year after surgery
Main finding
As reported in the abstract
- Preoperative abnormal glucose metabolism
- 80 (53 %)
- Preoperative diabetes mellitus (DM)
- 56
- Preoperative impaired glucose regulation (IGR)
- 24
- Improved glucose metabolism at 1 year, with significant reduction in homeostasis model assessment of insulin resistance (HOMA-IR)
- 57 patients
- DM at 1 year
- 20
- IGR at 1 year
- 16
Observational data: associations, not effects.
Further findings
Timing of improvement · 3 and 6 months after surgery
- Improvements mainly observed at 3 and 6 months after surgery
Clinical features of persistent DM or IGR at 1 year vs NGT · 1 year after surgery
- Higher prevalence of hypertension, hyperlipidemia, fatty liver and abnormal bone metabolism vs NGT
Original publication
The outcome of abnormal glucose metabolism and its clinical features in patients with Cushing’s disease after curative surgery. Diabetes Res Clin Pract. Published 23 July 2025. doi:10.
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