The impact of triglyceride-glucose index on ischemic stroke: a systematic review and meta-analysis
Pooled result · Risk of IS in the general populationResult — go to the resultOdds ratio 1.37 95% CI 1.22–1.54Authors' conclusion
TyG index has potential value in optimizing risk stratification for IS in the general population. Furthermore, there is a significant association between high TyG index and many adverse outcomes of stroke, especially stroke recurrence and high mortality. Future studies should focus on multi-center and multi-regional designs in order to further explore the relationship between IS and TyG index.
Study context
- Population
- General population and ischemic stroke (IS) patients; studies on triglyceride and glucose (TyG) index and stroke, databases searched from inception to April 4, 2022
- Participants
- 592,635 participants18 studies
- Comparison
- Higher vs lower TyG index
- Outcome
- IS occurrence in the general population
Pooled result
Risk of IS in the general population
Odds ratio
1.37
95% CI 1.22–1.54
Higher TyG indexvs Lower TyG index
OR 1.37 (95% CI 1.22–1.54)
As reported in the abstract
Further pooled results
| Outcome | OR (95% CI) | |
|---|---|---|
| Stroke recurrence in IS patients | 1.50 (1.19–1.89) | |
| Mortality in IS patients | 1.40 (1.14–1.71) | |
| Poor functional outcomes in IS patientsNo correlation | 1.12 (0.88–1.43) | |
| Neurological worsening in IS patientsNo correlation | 1.76 (0.79–3.95) | |
| 0.20.5125Odds ratio (log scale) |
- Poor functional outcomes in IS patients: n = 38,301 with neurological worsening; high heterogeneity (P = 0.000; I2 = 77.20%)
Original publication
The impact of triglyceride-glucose index on ischemic stroke: a systematic review and meta-analysis. Cardiovasc Diabetol. Published 6 January 2023. doi:10.
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