The effects of policosanol supplementation on blood glucose: A systematic review and dose-response meta-analysis of randomized controlled trials
Pooled result · Blood glucoseResult — go to the resultWMD −2.24 mg/dl 95 % CI −4.05 to −0.42Authors' conclusion
Policosanol supplementation might improve blood glucose.
Study context
- Population
- RCTs of policosanol supplementation; databases searched until February 9, 2023
- Participants
- 2,680 participants25 trials
- Comparison
- Policosanol supplementation vs placebo
- Outcome
- Blood glucose (WMD before and after administration)
Methodological detailsrandom-effects or fixed-effects meta-analysis
- Random-effects or fixed-effects meta-analysis
Pooled result
Blood glucose
WMD
−2.24 mg/dl
95 % CI −4.05 to −0.42
P = 0.01
Policosanolvs Placebo
WMD −2.24 mg/dl (95 % CI −4.05 to −0.42); P = 0.01
As reported in the abstract
Further pooled results
Glucose, subgroups
- Significant reduction with duration <24 weeks
- Significant reduction in individuals <50 years
- Significant reduction at 10 mg/day
Dose-response: dose and duration vs glucose change
- No evidence of non-linear relationship with dose
- P-nonlinearity = 0.52
- No evidence of non-linear relationship with duration
- P-nonlinearity = 0.52
Original publication
The effects of policosanol supplementation on blood glucose: A systematic review and dose-response meta-analysis of randomized controlled trials. Diabetes Res Clin Pract. Published 18 May 2024. doi:10.
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