The Effect of Vitamin D Supplementation on Hypothyroidism in the Randomized Controlled D-Health Trial
Primary result · Incident hypothyroidismResult — go to the resultHazard ratio 0.89 95% CI 0.71–1.12Authors' conclusion
Vitamin D supplementation did not reduce the incidence of hypothyroidism overall
Study context
- Population
- Australians aged 60 years and over in the D-Health Trial; those who died or were dispensed levothyroxine in the first year excludedmain analysis
- Participants
- 17,851 participants
- Comparison
- Vitamin D3 60,000 IU/month vs placebo
- Vitamin Dn = 8,939
- Placebon = 8,912reference
- Primary endpoint
- Hypothyroidism (tertiary outcome of D-Health): time to first prescription of levothyroxine
- Follow-up
- From 12 months after randomization; median 4.1 years (IQR 4.1-4.1)
Methodological detailsdouble-blind, placebo-controlled
- Double-blind
- Placebo-controlled
Primary result
Incident hypothyroidism · median 4.1 years
Hazard ratio
0.89
95% CI 0.71–1.12
Events by treatment group
Vitamin Dvs Placebo
HR 0.89 (95% CI 0.71–1.12)
As reported in the abstract
Further findings
Hypothyroidism incidence by sex (subgroups)
- Females: HR (CI 0.58-1.06); some suggestion of an effect
- 0.78
- Males: HR (CI 0.74-1.50); no effect
- 1.06
- p interaction
- 0.20
Original publication
The Effect of Vitamin D Supplementation on Hypothyroidism in the Randomized Controlled D-Health Trial. Thyroid. Published 5 October 2023. doi:10.
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