The comprehensive evaluation of oral and fecal microbiota in patients with acromegaly
Authors' conclusion
Patients with acromegaly show distinct gut microbiota profiles, and it is evident that factors beyond the GH/IGF-1 axis play a role in shaping the gut microbiota of individuals with acromegaly.
Study context
- Population
- Patients with acromegaly (treated and followed up, or newly diagnosed) and healthy participants
- Participants
- 103 / 15 / 34
- Exposure
- Treated acromegaly vs newly diagnosed acromegaly vs healthy controls
- Acromegalyn = 103
- Newly diagnosed acromegalyn = 15
- Healthy controlsn = 34reference
- Outcome
- Oral and fecal microbiota (16S rRNA sequencing)
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
- Firmicutes/Bacteroidetes ratio significantly lower in treated (medical and/or surgical) acromegaly than in healthy controls
- Significant difference in fecal and oral microbiota of acromegaly with disease control vs healthy controls
- Significant difference in fecal and oral microbiota of acromegaly without disease control
- No clear relationship between disease control status, intestinal polyps, T2D and oral and gut microbiota composition in acromegaly patients with different treatments
Observational data: associations, not effects.
Original publication
The comprehensive evaluation of oral and fecal microbiota in patients with acromegaly. Pituitary. Published 19 August 2024. doi:10.
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