The Clinical Outcomes of Preclinical and Clinical Obesity Across Multiple Cohorts
Authors' conclusion
The prevalence of clinical obesity varied by age, sex, and country. Overall, the prevalence was lower among older adults and men. Clinical obesity was associated with increased cardiovascular event risk across cohorts and increased all-cause mortality risk in NHANES
Study context
- Population
- Participants of China Health and Retirement Longitudinal Study (CHARLS), English Longitudinal Study of Aging (ELSA) and National Health and Nutrition Examination Survey (NHANES); four categories by obesity and organ dysfunction statusCHARLS, ELSA, NHANES cohorts
- Exposure
- Clinical obesity vs preclinical obesity and vs non-obesity without dysfunctions
- Outcome
- Prevalence of clinical obesity
Methodological detailsmulti-cohort (CHARLS, ELSA, NHANES), Cox proportional hazards models
- Multi-cohort (CHARLS, ELSA, NHANES)
- Cox proportional hazards models
Main finding
As reported in the abstract
Prevalence, CHARLS
2.50%
Prevalence, ELSA
6.18%
Prevalence, NHANES
9.08%
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Cardiovascular risk, CHARLSClinical obesityvs Preclinical obesity | 2.49 (1.32–4.70) | |
| Cardiovascular risk, ELSAClinical obesityvs Preclinical obesity | 1.80 (1.02–3.17) | |
| All-cause mortality, NHANESClinical obesityvs Preclinical obesity | 1.88 (1.23–2.87) | |
| Cardiovascular mortality, NHANESClinical obesityvs Preclinical obesity | 3.11 (1.49–6.50) | |
| 0.10.31310Hazard ratio (log scale) |
Cardiovascular outcomes vs non-obesity without dysfunctions
- Clinical obesity and non-obesity with dysfunctions showed higher risks of cardiovascular outcomes vs non-obesity without dysfunctions
Original publication
The Clinical Outcomes of Preclinical and Clinical Obesity Across Multiple Cohorts. Obesity (Silver Spring). Published 10 July 2026. doi:10.
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