The Automatic Correction Boluses in an Advanced Hybrid Closed-Loop System: Algorithm Performance and Clinical Implications
Authors' conclusion
ABs represent a substantial component of insulin delivery in MiniMed 780G users. Higher AB contribution is associated with poorer glycemic outcomes. Identified thresholds may support system optimization in clinical practice.
Study context
- Population
- Individuals with T1D using the MiniMed 780G for ≥6 months with ≥80% auto-mode usage, four diabetes centers in Sicily
- Participants
- 287 individuals
- Outcome
- Contribution of automatic correction boluses (ABs) to total daily insulin dose (TDD) and total bolus insulin
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Contribution of ABs to insulin delivery
ABs as share of TDD
18.3%
ABs as share of total bolus insulin
33.1%
Observational data: associations, not effects.
Further findings
Determinants of AB/TDD
- AB/TDD higher in pediatric participants and inversely associated with diabetes duration and AID use
- Active insulin time and carbohydrate intake independently predicted AB/TDD
AB/TDD and glycaemic outcomes
- Higher AB/TDD associated with lower TIR, higher glucose variability, TAR and GMI
- In pediatric participants, higher AB/TDD also associated with reduced TBR
AB/TDD thresholds (ROC)
- AB/TDD ≤20.3% predicted TIR >70%, AUC
- 0.785
- AB/TDD ≤18.6% predicted GMI <7%, AUC
- 0.828
Original publication
The Automatic Correction Boluses in an Advanced Hybrid Closed-Loop System: Algorithm Performance and Clinical Implications. J Diabetes Sci Technol. Published 7 May 2026. doi:10.
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