The association between android‐to‐gynoid lean mass ratio and all‐cause and specific‐cause mortality in US adults: A prospective study
Authors' conclusion
AGLR evaluated by DXA was associated with a higher risk of all-cause and specific-cause mortality among the general population from the US NHANES cohort.
Study context
- Population
- Adults aged ≥20 years, US NHANES 2003–2006 and 2011–2018
- Participants
- 18,542 adults
- Exposure
- Per SD increase in android/gynoid lean mass ratio
- Outcome
- All-cause, CVD and cancer mortality (registry linkage)
- Follow-up
- Median 6.9 years
Methodological detailsprospective
- Prospective
Main finding
As reported in the abstract
Mortality per SD increase in AGLR
- Deaths, all-cause
- 1412
- Deaths, CVD
- 435
- Deaths, cancer
- 340
- All-cause mortality, HR per SD increase in AGLR (Model 4), 95% CI 1.40-1.67
- 1.53
- Cancer mortality, HR per SD increase in AGLR (Model 4), 95% CI 1.30-1.87
- 1.56
- CVD mortality, HR per SD increase in AGLR (Model 4), 95% CI 1.47-1.84
- 1.64
Observational data: associations, not effects.
Further findings
- Associations robust in sensitivity analyses and present in most subgroups
Original publication
The association between android‐to‐gynoid lean mass ratio and all‐cause and specific‐cause mortality in US adults: A prospective study. Diabetes Obes Metab. Published 7 November 2024. doi:10.
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