Structural and molecular imaging-based characterization of soft tissue and vascular calcification in hyperphosphatemic familial tumoral calcinosis
Authors' conclusion
This first systematic assessment of calcifications in a cohort of patients with HFTC has identified the early onset, prevalence, and extent of calcification.
Study context
- Population
- Patients with hyperphosphatemic familial tumoral calcinosis (HFTC)
- Participants
- 11 patients
- Outcome
- Ectopic calcification
Methodological detailsCT and 18F-NaF PET/CT, fourier-transform infrared (FTIR) spectroscopy, Vascular microcalcification scores by 18F-NaF PET/CT in 6 patients
- CT and 18F-NaF PET/CT
- FTIR spectroscopy
- Vascular microcalcification scores by 18F-NaF PET/CT in 6 patients
Main finding
As reported in the abstract
- Patients with ectopic calcifications, predominantly near joints and distal extremities
- 82%
- Total calcific burden per patient (n = 9)
- 823.0 ± 670.1 cm³
- Lesion volume (n = 27)
- 282.5 ± 414.8 cm³
- Brain parenchyma calcification
- 50%
- Abdominal aorta calcification
- 50%
- Carotid calcification
- 73%
- Coronary calcification
- 50%
Observational data: associations, not effects.
Further findings
Total calcific burden per patient (CT)
- Total calcific burden per patient (n = 9), considerable heterogeneity
- 823.0 ± 670.1 cm³
Lesion volume (CT)
- Lesion volume (n = 27)
- 282.5 ± 414.8 cm³
- Largest lesions at the hips and shoulders
Calcification at other anatomic locations
- Brain parenchyma
- 50%
Vascular calcification
- Abdominal aorta
- 50%
- Carotid
- 73%
- Coronaries
- 50%
18F-NaF PET activity
- 18F-NaF PET differentiated active vs quiescent calcifications
- 18F-NaF-avid, CT-negative calcification in a 17-year-old patient, implicating early onset vascular calcification
Original publication
Structural and molecular imaging-based characterization of soft tissue and vascular calcification in hyperphosphatemic familial tumoral calcinosis. J Bone Miner Res. Published 24 July 2024. doi:10.
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