Stress hyperglycemia ratio and physical frailty in heart failure with preserved ejection fraction (HFpEF)
Authors' conclusion
A higher SHR was independently associated with poorer physical function in frail older adults with HFpEF. These findings suggest that stress-related dysglycemia may contribute to functional decline in this population, highlighting the potential utility of SHR as a metabolic marker of frailty severity and cardiovascular vulnerability.
Study context
- Population
- Frail adults aged > 65 years with confirmed HFpEF and Montreal cognitive assessment (MoCA) score < 26; frailty = ≥ 3 of 5 Fried criteria295 screened
- Participants
- 204 adults
- Exposure
- Stress hyperglycemia ratio (SHR) > 1 vs SHR ≤ 1
- Outcome
- Physical function assessed by gait speed (m/s)
Methodological detailsconsecutive enrolment
- Consecutive enrolment
Main finding
As reported in the abstract
Gait speed
P = 0.0004
Observational data: associations, not effects.
Original publication
Stress hyperglycemia ratio and physical frailty in HFpEF. Cardiovasc Diabetol. Published 7 December 2025. doi:10.
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