Strain-specific gut microbial signatures in type 2 diabetes identified in a cross-cohort analysis of 8,117 metagenomes
Authors' conclusion
In summary, our study provides robust cross-cohort microbial signatures in a strain-resolved manner and offers new mechanistic insights into T2D.
Study context
- Population
- Individuals with T2D, prediabetes and normoglycemic status in the United States, Europe, Israel and Chinametagenomes, 10 cohorts
- Participants
- 8,117 individuals
- Exposure
- T2D vs prediabetes vs normoglycemia
- Outcome
- Gut microbial species associated with T2D
Methodological details10 cohorts, shotgun metagenomics, strain-resolved
- 10 cohorts
- Shotgun metagenomics
- Strain-resolved
Main finding
As reported in the abstract
Phylogenetically diverse species with dysbiosis associated with T2D (false discovery rate < 0.10), e.g. enriched Clostridium bolteae and depleted Butyrivibrio crossotus
19
Species with within-species strain phylogenetic diversity explaining inter-individual differences in T2D risk, e.g. Eubacterium rectale
27
Observational data: associations, not effects.
Original publication
Strain-specific gut microbial signatures in type 2 diabetes identified in a cross-cohort analysis of 8,117 metagenomes. Nat Med. Published 25 June 2024. doi:10.
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