Spatial proteomics of human diabetic kidney disease, from health to class III
Authors' conclusion
Using the STEP pipeline, we found alterations in protein expression, cellular phenotypic composition and microenvironment structure with DKD progression, demonstrating the power of this pipeline to reveal the pathophysiology of human DKD.
Study context
- Population
- Human kidney tissue sections from individuals with diabetes, healthy kidneys or diabetic kidney disease (DKD) classes IIA–III23 tissue sections
- Comparison
- Healthy kidneys from individuals with diabetes vs DKD classes IIA, IIA-B, IIB and III
- Outcome
- Expression of 21 proteins, cellular composition and neighbourhoods
Methodological detailsspatial tissue proteomics, multiplexed immunofluorescence
- Spatial tissue proteomics
- Multiplexed immunofluorescence
Main finding
As reported in the abstract
- Cellular clusters (kidney compartments/cell types) identified
- 11
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Spatial proteomics of human diabetic kidney disease, from health to class III. Diabetologia. Published 22 July 2024. doi:10.
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