Sodium–glucose cotransporter 2 inhibitors reduce the risk of incident type 2 diabetes in people with heart failure without diabetes: An analysis of real‐world, cohort data
Main finding · Incident T2DResult — go to the resultHazard ratio 0.71 95% CI 0.63–0.75Authors' conclusion
Treatment with SGLT2is in patients with HF was associated with a reduced risk of incident T2D, most strikingly in people with prediabetes.
Study context
- Population
- Patients with heart failure (HF) without baseline diabetes prescribed ACE inhibitors or angiotensin II receptor blockers, 95 global health care organizations39,168 each arm matched
- Participants
- 484,643 patients
- Exposure
- ACEi/ARB with SGLT2i vs ACEi/ARB without SGLT2i
- Treatmentn = 42,018
- Referencen = 442,625reference
- Outcome
- Incident T2D
Methodological detailspropensity-score matched 1:1, 95 global health care organizations, real-world data
- Propensity-score matched 1:1
- 95 global health care organizations
- Real-world data
Main finding
As reported in the abstract
Hazard ratio
0.71
95% CI 0.63–0.75
Treatmentvs Reference
HR 0.71 (95% CI 0.63–0.75)
Observational data: associations, not effects.
Secondary outcomes
Incident T2D, subgroup with prediabetes
| HR (95% CI) | ||
|---|---|---|
| SGLT2is | 0.62 (0.45–0.80) | |
| 0.512Hazard ratio (log scale) |
Incident T2D, dapagliflozin subgroup
| HR (95% CI) | ||
|---|---|---|
| Dapagliflozin | 0.47 (0.39–0.56) | |
| 0.20.5125Hazard ratio (log scale) |
Incident T2D, empagliflozin subgroup
| HR (95% CI) | ||
|---|---|---|
| Empagliflozin | 0.81 (0.70–0.93) | |
| 0.512Hazard ratio (log scale) |
- Incident T2D, empagliflozin subgroup: Reduction in incident T2D greater with dapagliflozin than empagliflozin
Original publication
Sodium–glucose cotransporter 2 inhibitors reduce the risk of incident type 2 diabetes in people with heart failure without diabetes: An analysis of real‐world, cohort data. Diabetes Obes Metab. Published 7 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →