Short Stature due to Bioinactive Growth Hormone (Kowarski Syndrome)
Authors' conclusion
The diversity of genetic defects underlying Kowarski syndrome (KS) will provide new insights into growth hormone insensitivity. As the availability of genetic analysis, including functional investigations expands, researchers will identify new underlying genetic pathways.
Study context
- Population
- Children with short stature due to bioinactive GH (Kowarski syndrome) reported in the literature
- Comparison
- Kowarski syndrome (KS) cases vs GH deficiency
- Outcome
- SDS for height and IGF-1
Methodological detailsClinical and laboratory data collected from KS cases reported in the literature
- Clinical and laboratory data collected from KS cases reported in the literature
Main finding
As reported in the abstract
- KS cases have lower SDSs for height and IGF-1 compared to GH deficiency
Original publication
Short Stature due to Bioinactive Growth Hormone (Kowarski Syndrome). Endocr Pract. Published 30 August 2023. doi:10.
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