Sex steroids and androgen biomarkers in the healthy man study: within-person variability and impact of fasting
Authors' conclusion
This study provides estimates of variability in serum testosterone and the best androgen biomarkers that may prove useful for future studies of androgen action in male ageing.
Study context
- Population
- Elite healthy men over 40 years of age in excellent, asymptomatic health9 blood samples each
- Participants
- 325 participants
- Outcome
- Within-person variability of serum testosterone (and dihydrotestosterone (DHT), E2, E1) measured by liquid chromatography-mass spectrometry (LCMS)
- Follow-up
- 3 months
Methodological detailsmulti-sampling, 3 months
- Multi-sampling
- 3 months
Main finding
As reported in the abstract
Within-person variability of serum sex steroids · within day and between day, week, month and quarter
- Within-person variability estimates were stable other than an increase due to fasting
Observational data: associations, not effects.
Further findings
- Androgen biomarkers most sensitive to age and testosterone among widely used biochemical and anthropometric variables in middle-aged and older men were identified
Original publication
Sex steroids and androgen biomarkers in the healthy man study: within-person variability and impact of fasting. Eur J Endocrinol. Published 23 December 2023. doi:10.
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