Sex comparisons in the association of prediabetes and type 2 diabetes with cognitive function, depression, and quality of life: The Maastricht study
Authors' conclusion
In general, T2D was associated with worse cognitive function, depression, and poorer QoL. The strength of these associations was similar among women and men.
Study context
- Population
- Adults aged 40–75 years, 50% women, 25% T2D (The Maastricht study)
- Participants
- 7,639 adults
- Exposure
- Prediabetes and T2D vs normal glucose metabolism, by sex
- Outcome
- Sex-specific associations of prediabetes and T2D with cognitive function, depression, and physical and mental QoL
Methodological detailspopulation-based, multiple regression models with interaction terms
- Population-based
- Multiple regression models with interaction terms
Main finding
As reported in the abstract
Each group vs normal glucose metabolismEstimate (95% CI)
T2D (women)
OR of cognitive impairment 1.29(0.96–1.72)
T2D (men)
OR of cognitive impairment 1.39(1.10–1.75)
T2D (women)
OR of major depressive disorder 1.19(0.69–2.04)
T2D (men)
OR of major depressive disorder 1.68(1.02–2.75)
- T2D (women)
- MD in physical quality of life (QoL) score (0-100) −2.09 (95% CI −2.92 to −1.25)
- T2D (men)
- MD in physical QoL score (0-100) −1.81 (95% CI −2.48 to −1.13)
- T2D (women)
- MD in mental QoL score −0.90 (95% CI −1.79 to −0.02)
- T2D (men)
- MD in mental QoL score −0.52 (95% CI −1.23 to 0.20)
Observational data: associations, not effects.
Original publication
Sex comparisons in the association of prediabetes and type 2 diabetes with cognitive function, depression, and quality of life: The Maastricht study. Diabet Med. Published 4 May 2023. doi:10.
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