Serum and urinary 5-hydroxyindolacetic acid, serotonin, chromogranin A, and NT-proBNP for the detection of carcinoid heart disease
Authors' conclusion
s5HIAA is highly sensitive and specific for CHD detection. It could be used as a pre-screening tool in centres where systematic and regular echocardiography by an expert cardiologist is not performed in this population.
Study context
- Population
- Adults aged ≥18 years with advanced/metastatic ileum or lung NET, or a NET of any or unknown primary with clinical CS and/or u5HIAA twice greater than the upper limit of normal, managed at the Lyon-EURACAN Center of Excellence (French CrusoeNET cohort)19 with carcinoid heart disease (CHD)
- Participants
- 138 adults
- Outcome
- Performance of biomarkers (in particular s5HIAA) for detection of carcinoid heart disease (CHD) by expert echocardiography
Methodological detailsexplorative ancillary study of the French CrusoeNET cohort, single-centre, Echocardiography by 1 of 3 expert cardiologists
- Explorative ancillary study of the French CrusoeNET cohort
- Single-centre
- Echocardiography by 1 of 3 expert cardiologists
Performance
As reported in the abstract
CHD detection
| Test or model | ROC curve | Threshold | Sensitivity | Specificity |
|---|---|---|---|---|
| s5HIAA | 0.85 [0.75-0.94], P < .0001 | 757 nmol/L | 84% | 80% |
s5HIAA
ROC curve0.85 [0.75-0.94], P < .0001
Threshold757 nmol/L
Sensitivity84%
Specificity80%
Further findings
Correlation of s5HIAA with u5HIAA
- ρ
- 0.824 [0.76-0.88], P < .0001
Original publication
Serum and urinary 5-hydroxyindolacetic acid, serotonin, chromogranin A, and NT-proBNP for the detection of carcinoid heart disease. Eur J Endocrinol. Published 27 November 2024. doi:10.
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