Secretin infusion decreases food intake in healthy men—a randomized, placebo-controlled, double-blind, crossover study
Authors' conclusion
In healthy men, secretin infusion decreased ad libitum food intake concomitantly with a postprandial increase in BAT activity as assessed by thermal imaging-measured supraclavicular skin temperature.
Study context
- Population
- Healthy mencrossover
- Participants
- 25 men
- Comparison
- Secretin i.v. infusion vs placebo
- Primary endpoint
- Ad libitum food intake
- Follow-up
- After 5 h of infusion
Methodological detailsplacebo-controlled, double-blind, crossover, 2-month wash-out period between infusions
- Placebo-controlled
- Double-blind
- Crossover
- 2-month wash-out period between infusions
Primary result
As reported in the abstract
after 5 h
Decrease
173 ± 88 kcal
95% CI 0.76–0.99
P = 0.039
Further findings
Ad libitum meal duration
- Secretin did not alter ad libitum meal duration
Brown adipose tissue (BAT) activity (thermal imaging-measured supraclavicular skin temperature)
- Secretin acutely decreased BAT activity but increased it postprandially vs placebo
Postprandial physiology
- Acetaminophen-assessed gastric emptying not affected by secretin
- Secretin increased gallbladder volume, bile acid synthesis, and circulating lipase, amylase and TG, while decreasing plasma Na+
Safety
| Outcome | More adverse events (%) (95% CI) | P value |
|---|---|---|
| Adverse events (headache, nausea, diarrhea, vomiting)More with secretin | 24.0 ± 10.8 (0.3–1) | P = 0.025 |
Original publication
Secretin infusion decreases food intake in healthy men—a randomized, placebo-controlled, double-blind, crossover study. Eur J Endocrinol. Published 18 November 2024. doi:10.
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