Salivary Diurnal Glucocorticoid Profiles in Monozygotic Twins With Intratwin Birthweight Differences
Authors' conclusion
In monozygotic twins with intratwin bw differences, intratwin catch-up growth showed a moderate influence on intratwin differences in morning cortisol concentrations. We observed no differences regarding diurnal patterns. In contrast, in all groups, we found significant intratwin correlations for cortisol and cortisone over the day and a pronounced graphic alignment of cortisol diurnal patterns. We therefore suggest a predominant significance of the genetic background compared with bw differences on cortisol metabolism.
Study context
- Population
- Monozygotic twins with intratwin birthweight differences; mean age 6.9 years; salivary cortisol and cortisone at 7, 13, 18 and 21 hours by LC-MS/MS
- Participants
- 46 twin pairs
- Exposure
- Twin pairs with bw differences ≥1 SDS vs <1 SDS
- Concordantn = 29reference
- Discordantn = 17
- Outcome
- Intratwin correlations and diurnal patterns of salivary glucocorticoids
Main finding
As reported in the abstract
- Significant or highly significant intratwin correlations in all twin pairs at 3 of 4 time points (cortisol) and 4 of 4 (cortisone)
- Distinct alignment of diurnal cortisol patterns in all groups
- No intratwin differences in diurnal patterns (mixed linear modeling)
Observational data: associations, not effects.
Further findings
Influence of catch-up growth on intratwin cortisol differences (regression) · 7:00 hours
- Significant influence of catch-up growth: lower cortisol in smaller twins with more catch-up growth, adj. R2
- 0.159
- ß
- −3.71
- P
- P = 0.014
- f2
- 0.19
Intratwin correlations of cortisol and cortisone
- Significant or highly significant intratwin correlations in all twin pairs at 3 of 4 (cortisol) and 4 of 4 (cortisone) time points
Diurnal patterns
- Mixed linear modeling showed no intratwin differences in diurnal patterns; distinct graphic alignment of diurnal cortisol patterns in all groups
Original publication
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