Risk of dementia after initiation of sodium-glucose cotransporter-2 inhibitors versus dipeptidyl peptidase-4 inhibitors in older adults with type 2 diabetes: A five-year retrospective cohort analysis of 160,752 patients
Main finding · New-onset dementiaResult — go to the resultHazard ratio 0.54 95 % CI 0.51–0.57Authors' conclusion
Compared to DPP-4i, SGLT2i use is associated with a lower risk of dementia in older adults with T2DM, with consistent benefits observed across diverse populations and patient subgroups. These findings highlight the potential of SGLT2i as a preventive strategy for cognitive decline and support further investigation in randomized controlled trials.
Study context
- Population
- Adults aged ≥65 years with T2D who initiated SGLT2i or DPP4i between January 1, 2013, and November 30, 2024matched cohort
- Participants
- 80,376 vs 80,376
- Exposure
- SGLT2i vs DPP4i initiation
- SGLT2in = 80,376
- DPP4in = 80,376reference
- Outcome
- New-onset dementia
Methodological detailspropensity-score matched, TriNetX electronic health records network
- Propensity-score matched
- TriNetX electronic health records network
Main finding
As reported in the abstract
Hazard ratio
0.54
95 % CI 0.51–0.57
P < 0.001
SGLT2ivs DPP4i
HR 0.54 (95 % CI 0.51–0.57); P < 0.001
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95 % CI) | P value | |
|---|---|---|---|
| Dementia-related drug use | 0.69 (0.64–0.74) | P < 0.001 | |
| Alzheimer's disease | 0.53 (0.48–0.60) | P < 0.001 | |
| Vascular dementia | 0.52 (0.46–0.58) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
Subgroup analyses
- Subgroup analyses showed consistent protective effects
Original publication
Risk of dementia after initiation of sodium-glucose cotransporter-2 inhibitors versus dipeptidyl peptidase-4 inhibitors in older adults with type 2 diabetes: A five-year retrospective cohort analysis of 160,752 patients. Diabetes Res Clin Pract. Published 21 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →