Relationship of high‐density lipoprotein subfractions and apolipoprotein A‐I with fat in the pancreas
Authors' conclusion
Fat in the pancreas is inversely associated with the circulating levels of large HDL particles and apo A-I. Purposely designed studies are warranted to investigate the potential of fatty pancreas as an indicator of the risk of cardiovascular diseases.
Study context
- Population
- Individuals studied with MRI for fatty pancreas; High-density lipoprotein (HDL) subfractions classed as large, intermediate and small HDL
- Participants
- 170 individuals
- Exposure
- Fatty pancreas vs no fatty pancreas
- Outcome
- Associations of HDL subfractions and apo A-I with fatty pancreas
Methodological detailsMRI on a single 3.0-Tesla scanner, unadjusted and adjusted logistic regression
- MRI on a single 3.0-Tesla scanner
- Unadjusted and adjusted logistic regression
Main finding
As reported in the abstract
Large HDL, apo A-I and fatty pancreas
Increase in likelihood of fatty pancreas per unit decrease in large HDL, most adjusted model (P < .001)
93%
Increase in likelihood of fatty pancreas per unit decrease in apo A-I, most adjusted model (P = .012)
45%
Observational data: associations, not effects.
Original publication
Relationship of high‐density lipoprotein subfractions and apolipoprotein A‐I with fat in the pancreas. Diabetes Obes Metab. Published 8 October 2024. doi:10.
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