Relationship between stress hyperglycaemic ratio (stress-hyperglycemia ratio (SHR)) and critical illness: a systematic review
Authors' conclusion
The ease of calculating the SHR from widely available admission glucose and HbA1c tests makes it a practical and valuable prognostic marker in clinical settings.
Study context
- Population
- Patients with acute or critical illnesses, with and without diabetes
- Outcome
- SHR and outcomes of critical illness
Pooled result
As reported in the abstract
- U-shaped or J-shaped relationship of SHR with outcomes: both low and high SHRs associated with increased mortality and morbidity
- SHR has significant predictive value in CVD (e.g., acute coronary syndrome, HF), cerebrovascular diseases (e.g., acute ischemic stroke, intracerebral hemorrhage) and infectious diseases (e.g., sepsis, pneumonia)
- SHR also plays a role in acute pancreatitis and certain cancers
- SHR = admission glucose / estimated mean glucose derived from HbA1c
Original publication
Relationship between stress hyperglycaemic ratio (SHR) and critical illness: a systematic review. Cardiovasc Diabetol. Published 2 May 2025. doi:10.
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