Relationship Between Insulin-Like Growth Factor 2 Receptor and Coronary Artery Disease
Authors' conclusion
Higher levels of IGF2R are associated with an increased risk of incident CAD and CAD-related mortality.
Study context
- Population
- UK Biobank participants with plasma IGF2R concentration or genetic data; donors of human liver specimens51,581 with plasma IGF2R
- Exposure
- High vs low tertile of plasma IGF2R
- Outcome
- CAD incident and CAD mortality
Methodological detailsUK Biobank, polygenic risk score, human liver specimen analysis
- UK Biobank
- Polygenic risk score
- Human liver specimen analysis
Main finding
As reported in the abstract
High tertile vs Low tertileHazard ratio (95% CI)
CAD incident
1.23(1.13–1.33)
CAD mortality
1.30(1.01–1.68)
- One-unit increment of plasma IGF2R: higher risk of coronary artery disease (CAD) incident
- 39%
- One-unit increment of plasma IGF2R: higher risk of CAD mortality
- 60%
Observational data: associations, not effects.
Further findings
| Outcome | CAD donors | CAD-free donors | P value |
|---|---|---|---|
| Hepatic IGF2R level (immunohistochemistry), CAD vs no CAD cadaveric donors120% higher hepatic IGF2R level | 2.20 ± 1.53 | 1.00 ± 0.96 | P < 0.01 |
- Hepatic IGF2R level (immunohistochemistry), CAD vs no CAD cadaveric donors: 10 donors with CAD, 11 without
IGF2R polygenic risk score (n=487 034 with genetic data)
- One-unit increment in IGF2R polygenic risk score: higher risk of CAD incident
- 4%
- One-unit increment in IGF2R polygenic risk score: higher risk of CAD mortality
- 5%
Original publication
Relationship Between Insulin-Like Growth Factor 2 Receptor and Coronary Artery Disease. Endocr Pract. Published 31 March 2026. doi:10.
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