Reduction in Postprandial Peak Glucose With Increased Technosphere Insulin Dosage
Authors' conclusion
The higher dose 2 reduced PPGE versus the current label recommended dose 1 within the two-hour postprandial timeframe without any new safety concerns. When confirmed with a larger study, this higher TI dosing recommendation may help patients and clinicians minimize immediate postprandial hyperglycemia when titrating TI for prandial glucose control.
Study context
- Population
- Patients with diabetes on basal-bolus insulin therapy; identical meal at both visits, Technosphere Insulin (TI) given immediately before the meal
- Participants
- 20 patients
- Comparison
- Higher TI dose vs label-calculated initial TI dose
- Outcome
- Mean peak 2-hour postprandial glucose concentration
- Follow-up
- 2 hours postprandial
Main finding
As reported in the abstract
Mean peak postprandial glucose · two hours
- Mean peak glucose reduced from 228.6 to 179.3 mg/dL at two hours
- Dose 2 vs Dose 1: P < 0.001
- Within-patient comparison: dose 1 (label dose) followed by ≈2× higher dose 2
Secondary outcomes
| Outcome | P value |
|---|---|
| Mean postprandial glucose excursion (PPGE) · 45 to 120 minutes postprandialDose 2 vs Dose 1 · significant reduction with dose 2 at 45 minutes | P = 0.008 |
| Mean postprandial glucose excursion (PPGE) · 45 to 120 minutes postprandialDose 2 vs Dose 1 · significant reduction with dose 2 at 120 minutes | P < 0.0001 |
Mean postprandial glucose excursion (PPGE) · 45 to 120 minutes postprandial
- Significant reductions in mean PPGE with dose 2 from 45 to 120 minutes
Safety
Hypoglycemia within 2-hour postprandial period
- Hypoglycemic events with dose 2 (one level 1, one level 2), in a single subject
FEV1 · before and after 2-hour postprandial period
- No significant changes in FEV1 after either dose of TI
Original publication
Reduction in Postprandial Peak Glucose With Increased Technosphere Insulin Dosage. J Diabetes Sci Technol. Published 14 July 2022. doi:10.
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