Real‐world performance of point‐of‐care metre, blood gas and laboratory glucose methods in Australian and American hospital inpatient cohorts
Authors' conclusion
In routine inpatient care, POC glucose metres show systematic bias, amplified by anaemia. Our results support local validation of glucose metre performance and identification of high-risk results to prompt confirmatory testing.
Study context
- Population
- Adult hospital inpatients in an Australian quaternary centre and the US MIMIC-IV dataset
- Exposure
- POC glucose metre vs blood gas and laboratory glucose
- Outcome
- Real-world inpatient POC glucose metre performance
Methodological detailstwo cohorts (Australian quaternary centre and US MIMIC-IV dataset), method-comparison of paired measurements within 15 min, sensitivity analysis within 5 min
- Two cohorts (Australian quaternary centre and US MIMIC-IV dataset)
- Method-comparison of paired measurements within 15 min
- Sensitivity analysis within 5 min
Main finding
As reported in the abstract
Parkes/Consensus Error Grids, both datasets: pairs within low-risk zones (A/B)
>98%
DTS grid zone A, Australian cohort
90.7%
DTS grid zone A, MIMIC-IV
75.7%
Observational data: associations, not effects.
Further findings
Pairing window narrowed to 5 min
- Modestly improved overall error in the Australian dataset but still did not meet ISO or FDA numerical targets
Effect of haemoglobin and pO2
- Low haemoglobin amplified negative bias at higher glucose
- pO2 strata showed no consistent impact
Original publication
Real‐world performance of point‐of‐care metre, blood gas and laboratory glucose methods in Australian and American hospital inpatient cohorts. Diabet Med. Published 17 June 2026. doi:10. 1111/ dme. 70395
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