Real‐world performance of point‐of‐care metre, blood gas and laboratory glucose methods in Australian and American hospital inpatient cohorts

Diabet MedPublished Retrospective cohort study

Authors' conclusion

In routine inpatient care, POC glucose metres show systematic bias, amplified by anaemia. Our results support local validation of glucose metre performance and identification of high-risk results to prompt confirmatory testing.

Study context

Population
Adult hospital inpatients in an Australian quaternary centre and the US MIMIC-IV dataset
Exposure
POC glucose metre vs blood gas and laboratory glucose
Outcome
Real-world inpatient POC glucose metre performance
Methodological detailstwo cohorts (Australian quaternary centre and US MIMIC-IV dataset), method-comparison of paired measurements within 15 min, sensitivity analysis within 5 min
  • Two cohorts (Australian quaternary centre and US MIMIC-IV dataset)
  • Method-comparison of paired measurements within 15 min
  • Sensitivity analysis within 5 min

Main finding

As reported in the abstract

Parkes/Consensus Error Grids, both datasets: pairs within low-risk zones (A/B)

>98%

DTS grid zone A, Australian cohort

90.7%

DTS grid zone A, MIMIC-IV

75.7%

Observational data: associations, not effects.

Further findings

Pairing window narrowed to 5 min

Modestly improved overall error in the Australian dataset but still did not meet ISO or FDA numerical targets

Effect of haemoglobin and pO2

Low haemoglobin amplified negative bias at higher glucose
pO2 strata showed no consistent impact

Original publication

Real‐world performance of point‐of‐care metre, blood gas and laboratory glucose methods in Australian and American hospital inpatient cohorts. Diabet Med. Published 17 June 2026. doi:10.1111/dme.70395

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