Quality of diabetes mellitus healthcare and metabolic control during transition from paediatric to adult care: A systematic review and meta‐analysis
Authors' conclusion
Findings suggest that the transition to adult care may negatively affect glycaemic control in emerging adults with diabetes, whereas structured transition programmes can neutralize this effect and prevent consequences. Further investigations are needed to develop evidence-based guidelines for optimizing transition interventions.
Study context
- Population
- Emerging adults with T1D or T2D transitioning from paediatric to adult healthcare; studies published 2018–2024, four databases20 studies
- Comparison
- HbA1c after vs before transition from paediatric to adult care
- Outcome
- Difference in HbA1c before and after transition
Methodological detailsPRISMA guidelines, ROBINS-I risk of bias assessment, non-randomized studies
- PRISMA guidelines
- ROBINS-I risk of bias assessment
- Non-randomized studies
Pooled result
As reported in the abstract
HbA1c difference post- vs pre-transition (negative = higher HbA1c post-transition)
MD
−1.75 mmol/mol
95% CI −5.24-1.75
Between Post-transition and Pre-transition
MD −1.75 mmol/mol (95% CI −5.24-1.75)
Further pooled results
| Outcome | MD (mmol/mol) (95% CI) | |
|---|---|---|
| HbA1c difference, subgroup with transition programmesBetween Post-transition and Pre-transition | 3.28 (0.44–6.12) | |
| HbA1c difference, subgroup with usual careBetween Post-transition and Pre-transition | −6.99 (−11.79 to −2.19) | |
| −15−10−50510Difference, mmol/mol (linear scale) |
- HbA1c difference, subgroup with transition programmes: 0.30% (95% CI 0.04%-0.56%); significant improvement of glycaemic control
- HbA1c difference, subgroup with usual care: −0.64% (95% CI −1.08% to −0.20%); significant worsening of glycaemic control
Studies with structured or semi-structured transition programme (11 studies)
- Reduction in HbA1c (improved glycaemic control)
- 3 studies
- No significant difference
- 8 studies
Studies with no transition programme (9 studies)
- Worsening of glycaemic control
- 4 studies
- No significant difference
- 5 studies
Original publication
Quality of diabetes mellitus healthcare and metabolic control during transition from paediatric to adult care: A systematic review and meta‐analysis. Diabet Med. Published 20 August 2025. doi:10.
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