Qualitative and Quantitative Analyses of Noninvasive Diagnosis of Insulinoma Using [18F]FB(ePEG12)12-Exendin-4 PET/CT
Authors' conclusion
18F-exendin-4 PET/CT demonstrated effective sensitivity for noninvasive insulinoma detection, offering a reliable and practical diagnostic alternative to invasive procedures for precise and prompt preoperative localization with functional evaluation. This novel imaging approach may therefore improve the management of patients with suspected insulinomas.
Study context
- Population
- Patients with biochemically confirmed hyperinsulinemic hypoglycemia suggestive of insulinoma; findings verified surgically and pathologically
- Participants
- 12 patients
- Comparison
- 18F-exendin-4 PET/CT vs conventional imaging
- 18F-exendin-4 PET/CTn = 12
- Outcome
- Insulinoma detection
Methodological detailsprospective, single-center, phase 2, interim report
- Prospective
- Single-center
- Phase 2
- Interim report
Performance
As reported in the abstract
| Test or model | Value | Sensitivity | Detection rate |
|---|---|---|---|
| 18F-exendin-4 PET/CT | 100% | 100% | |
| CT | 83% | 83% | |
| MRI | 63% | 63% | |
| Endoscopic US | 90% | 90% | |
| Selective arterial calcium stimulation | 89% | 89% |
Value
18F-exendin-4 PET/CT100%
CT83%
MRI63%
Endoscopic US90%
Selective arterial calcium stimulation89%
Sensitivity
18F-exendin-4 PET/CT100%
CT— not stated in the abstract
MRI— not stated in the abstract
Endoscopic US— not stated in the abstract
Selective arterial calcium stimulation— not stated in the abstract
Detection rate
18F-exendin-4 PET/CT— not stated in the abstract
CT83%
MRI63%
Endoscopic US90%
Selective arterial calcium stimulation89%
Further findings
Surgical confirmation and clinical outcome
- All identified lesions surgically confirmed as insulinomas, with complete clinical resolution of hypoglycemia after resection
Original publication
Qualitative and Quantitative Analyses of Noninvasive Diagnosis of Insulinoma Using [18F]FB(ePEG12)12-Exendin-4 PET/CT. J Clin Endocrinol Metab. Published 20 May 2025. doi:10.
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