Psychosocial burden in adrenocortical carcinoma patients
Authors' conclusion
Patients with ACC show high values for distress, FOP, and depression, which can only partly be explained by clinical characteristics. Our study suggests that psychosomatic support should be offered to all patients with ACC.
Study context
- Population
- Adults (≥18 years) with adrenocortical carcinoma (ACC); 56.2% female, median age 49 years, 14.3% newly diagnosed, 46.7% tumour-free, 39.0% metastaticincluded within 12 months
- Participants
- 105 adults
- Outcome
- Distress, FOP and depression
Methodological detailssingle-centre, observational
- Single-centre
- Observational
Main finding
As reported in the abstract
Elevated distress
62%
Elevated fear of progression (FOP)
59%
Major depression suggested by PHQ-9
41%
Observational data: associations, not effects.
Further findings
Health-related quality of life (HRQOL) (EORTC-QLQ-C30)
- Functioning score, median
- 62.2
- Symptom burden, median
- 33.3
- Fatigue and insomnia were prominent symptoms
- Tumour burden and treatment affected functioning and symptoms, with significant differences in appetite loss, diarrhoea, nausea, vomiting and financial difficulties
- Hormone excess showed no significant impact on these measures
Need for psychosomatic counselling
- Need indicated by questionnaires
- 80%
Original publication
Psychosocial burden in adrenocortical carcinoma patients. Eur J Endocrinol. Published 8 January 2026. doi:10.
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