Protocol for a feasibility and acceptability study for UK general population paediatric type 1 diabetes screening—the EarLy Surveillance for Autoimmune diabetes (EarLy Surveillance for Autoimmune (ELSA)) study
Study context
- Population
- Children aged 3–13 years in the UK general population, screened for islet-specific autoantibodies by dried blood spot at home, hospital or community settingsplanned
- Participants
- 20,000 children
Methodological detailsgeneral population screening, mixed methods (qualitative interviews), Powered to identify 60 children (0.3%) with T1D (stage 1-3), Children with ≥2 autoantibodies offered metabolic staging via oral glucose challenge testing, Feasibility: recruitment modalities and uptake compared by age, gender, ethnicity, deprivation and family history of diabetes, Acceptability: qualitative interviews with parents after completion, parents who decline or withdraw, and professional stakeholders
- General population screening
- Mixed methods (qualitative interviews)
- Powered to identify 60 children (0.3%) with T1D (stage 1-3)
- Children with ≥2 autoantibodies offered metabolic staging via oral glucose challenge testing
- Feasibility: recruitment modalities and uptake compared by age, gender, ethnicity, deprivation and family history of diabetes
- Acceptability: qualitative interviews with parents after completion, parents who decline or withdraw, and professional stakeholders
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Protocol for a feasibility and acceptability study for UK general population paediatric type 1 diabetes screening—the EarLy Surveillance for Autoimmune diabetes (ELSA) study. Diabet Med. Published 2 December 2024. doi:10.
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