Progressive Acceleration of Insulin Exposure Over 7 Days of Infusion Set Wear
Authors' conclusion
These results confirm/extend previous observations showing progressive acceleration of insulin exposure over IIS wear time.
Study context
- Population
- People with diabetes (A1C ≤8.5%, C-peptide <0.6 nmol/L, ≥6 months pump use)Pharmacokinetic (PK)/pharmacodynamic (PD) data obtained
- Participants
- 6 people
- Comparison
- Conventional Teflon angled insulin infusion set (IISs) vs investigational extended-wear IIS; PK over 7 days of IIS wear (pooled)
- Outcome
- Insulin lispro PK (0.15 U/kg bolus), pooled data from both groups, 5 h postbolus
- Follow-up
- Days 0 to 7
Main finding
As reported in the abstract
- Progressive decrease in tmax
- P < 0.001
- Progressive decrease in Cmax
- P < 0.05
- Progressive decrease in mean residence time
- P < 0.0001
- AUC0-300 declined by ∼24%
- P < 0.05
Original publication
Progressive Acceleration of Insulin Exposure Over 7 Days of Infusion Set Wear. Diabetes Technol Ther. Published 20 December 2022. doi:10.
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