Prevalence, risk factors, and optimal way to determine overweight, obesity, and morbid obesity in the first Dutch cohort of 2338 long-term survivors of childhood cancer: a DCCSS-LATER study
Authors' conclusion
Overweight occurs in almost half of long-term survivors. There was no overall increased incidence of overweight compared to controls. We identified factors associated with overweight, as well as subgroups of survivors in whom DXA can more reliably assess overweight.
Study context
- Population
- Adult long-term survivors of childhood cancer treated 1963–2002, DCCSS-LATER cohort; mean age 35.5 years, follow-up 28.3 years
- Participants
- 2,338 survivors
- Exposure
- Childhood cancer survivors vs LifeLines controls
- Outcome
- Prevalence of overweight and obesity, primarily defined by BMI
Methodological detailsnationwide, LifeLines cohort as reference
- Nationwide
- LifeLines cohort as reference
Main finding
As reported in the abstract
Overweight prevalence (BMI)
| Outcome | Men | Women |
|---|---|---|
| Overweight prevalence (BMI) | 46.3% | 44.3% |
| Obesity | 11.2% | 15.9% |
| Morbid obesity | 2.4% | 5.4% |
Observational data: associations, not effects.
Further findings
Risk factors associated with overweight
| aOR (95% CI) | ||
|---|---|---|
| Overweight at cancer diagnosis | 3.83 (2.19–6.69) | |
| Cranial radiotherapy | 3.21 (1.99–5.18) | |
| GHDSeparate model | 1.61 (1.00–2.59) | |
| 0.10.31310Adjusted odds ratio (log scale) |
Alternative overweight metrics
- Low high-molecular-weight (HMW) adiponectin present in survivors (insensitive overweight marker)
- 4.5%
- Additional overweight identified by DXA fat%-based classification, particularly after abdominal radiotherapy, total body irradiation, anthracyclines and platinum
- 30%
- Overweight prevalence similar using body mass index (BMI), waist circumference (WC), waist/hip ratio (WHR) and waist/height ratio (WHtR)
Original publication
Prevalence, risk factors, and optimal way to determine overweight, obesity, and morbid obesity in the first Dutch cohort of 2338 long-term survivors of childhood cancer: a DCCSS-LATER study. Eur J Endocrinol. Published 14 October 2023. doi:10.
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