Prevalence and Management of Complications of Percutaneous Ethanol Injection for Cystic Thyroid Nodules: A Systematic Review of Literature and Meta-analysis
Authors' conclusion
Complications of PEI for benign and CTNs are relatively common, but most are minor and usually transient, not requiring treatment. Dysphonia was a major complication, but it was uncommon and transient.
Study context
- Population
- Benign and cystic thyroid nodules (CTNs) treated with percutaneous ethanol injection (PEI); published observational studies plus consecutive patients with cytologically benign CTNs, Naples, Italy, June 2021–March 202448 studies + institutional data
- Participants
- 3,670 participants
- Outcome
- Prevalence of complications of PEI
Methodological detailsrandom effects meta-analysis, includes unpublished institutional retrospective data
- Random effects meta-analysis
- Includes unpublished institutional retrospective data
Pooled result
As reported in the abstract
Overall complications (967 of 3195 TNs), pooled prevalence, CI 25-40%, I2 92.7%
32%
Minor complications (952 of 3195 TNs), pooled prevalence, CI 25-40%, I2 92.7%
32%
Major complications (22 of 3670 TNs), pooled prevalence, CI 1-2%, I2 0%
2%
Safety
Local pain
- Pooled prevalence of local pain, CI 16-27, I2 90.3
- 21%
- Local pain typically transient and mild, sometimes moderate, requiring analgesics for few days
Dysphonia
- Pooled prevalence of dysphonia, CI 1-2, I2 0
- 1%
- Dysphonia transient, lasting from several hours to 12 months after PEI
Original publication
Prevalence and Management of Complications of Percutaneous Ethanol Injection for Cystic Thyroid Nodules: A Systematic Review of Literature and Meta-analysis. Thyroid. Published 7 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →